Lipodermaceuticals: Technological

Transformations

14

Rakesh Kumar Paul, Gajanand Sharma, Kaisar Raza,

and Om Prakash Katare

Abstract

Skin diseases are one of the major global burdens and constitute the 18th most

common noncommunicable diseases with affecting around 36.4 million people.

Several skin disorders like dermatitis, psoriasis, scabies, acne vulgaris, alopecia

areata, urticaria, and keratinocyte carcinoma have created a challenging task the

drugs to penetrate and reach to the target sites. Lipid-based delivery systems are

preferred more over conventional methods (chemical and physical) due to the

several complications like patient compliances, pain at the site of application, and

skin irritation. Currently, few lipodermal cosmeceutical products such as

Revitalift, Ameliox, SkinGenuity, Celltight EF, Noicellex, Regenerationscreme

Intensiv, NanoLipid Restore CLR, Psorisome, and Eye Essence have been

developed using approaches like liposomes, ethosomes, and lipid nanoparticles.

Application of these lipid-based technologies could be promising for the delivery

of the drug into the deeper tissues. The present book chapter deals with various

aspects which are pertinent for the development and translation of such carrier

systems.

Keywords

Clinical trials · Dermatokinetics · Lipid-based nanoformulations · Marketed

products · Skin diseases

R. K. Paul · K. Raza

Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of

Rajasthan, Ajmer, Rajasthan, India

G. Sharma · O. P. Katare (*)

Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, UGC-Centre of

Advanced Study, Panjab University, Chandigarh, India

e-mail: drkatare@yahoo.com

# The Author(s), under exclusive license to Springer Nature Singapore Pte

Ltd. 2022

R. C. Sobti, N. S. Dhalla (eds.), Biomedical Translational Research,

https://doi.org/10.1007/978-981-16-9232-1_14

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